Influence of cytokines on HIV-specific antibody-dependent cellular cytotoxicity activation profile of natural killer cells

L Wren; MS Parsons; G Isitman; RJ Center; AD Kelleher; I Stratov; NF Bernard; SJ Kent

Journal article

Influence of cytokines on HIV-specific antibody-dependent cellular cytotoxicity activation profile of natural killer cells

L Wren, MS Parsons, G Isitman, RJ Center, AD Kelleher, I Stratov, NF Bernard, SJ Kent

Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012

DOI: 10.1371/journal.pone.0038580

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Abstract

There is growing interest in HIV-specific antibody-dependent cellular cytotoxicity (ADCC) as an effective immune response to prevent or control HIV infection. ADCC relies on innate immune effector cells, particularly NK cells, to mediate control of virus-infected cells. The activation of NK cells (i.e., expression of cytokines and/or degranulation) by ADCC antibodies in serum is likely subject to the influence of other factors that are also present. We observed that the HIV-specific ADCC antibodies, within serum samples from a panel of HIV-infected individuals induced divergent activation profiles of NK cells from the same donor. Some serum samples primarily induced NK cell cytokine expressi..

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University of Melbourne Researchers

Stephen Kent Author

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Awarded by National Institute of Allergy and Infectious Diseases

Funding Acknowledgements

This study was supported by Australian National Health and Medical Research Council awards 510448 and 455350, Australian Research Council award LP0991498, and National Institutes of Health award R21AI081541. MSP is supported by a Canadian Institutes of Health Research Vanier Scholarship and a Michael Smith Foreign Study Supplement. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.